Article
Preliminary analysis of numerical chromosome abnormalities in reciprocal and Robertsonian translocation preimplantation genetic diagnosis cases with 24-chromosomal analysis with an aCGH/SNP microarray.
Journal of assisted reproduction and genetics - 1 Jan 2018
Xie Yanxin, Xu Yanwen, Wang Jing, Miao Benyu, Zeng Yanhong, Ding Chenhui, Gao Jun, Zhou Canquan
Abstract excerpt
PURPOSE: The aim of this study was to determine whether an interchromosomal effect (ICE) occurred in embryos obtained from reciprocal translocation (rcp) and Robertsonian translocation (RT) carriers who were following a preimplantation genetic diagnosis (PGD) with whole chromosome screening with an aCGH and SNP microarray. We also analyzed the chromosomal numerical abnormalities in embryos with aneuploidy in...
Topics
- Adult
- Case-Control Studies
- Chromosome Aberrations
- Comparative Genomic Hybridization
- DNA Copy Number Variations
- Female
- Fertilization in Vitro
- High-Throughput Nucleotide Sequencing
- Humans
- Microarray Analysis
- Pilot Projects
- Polymorphism, Single Nucleotide