Article
Molecular basis of arrhythmic substrate in ageing murine peroxisome proliferator-activated receptor γ co-activator deficient hearts modelling mitochondrial dysfunction.
Bioscience reports - 20 Dec 2019
Edling Charlotte E, Fazmin Ibrahim T, Saadeh Khalil, Chadda Karan R, Ahmad Shiraz, Valli Haseeb, Huang Christopher L-H, Jeevaratnam Kamalan
Abstract excerpt
INTRODUCTION: Ageing and chronic metabolic disorders are associated with mitochondrial dysfunction and cardiac pro-arrhythmic phenotypes which were recently attributed to slowed atrial and ventricular action potential (AP) conduction in peroxisome proliferator-activated receptor γ co-activator deficient (Pgc-1β-/-) mice. METHODS: We compared expression levels of voltage-gated Na+ channel (NaV1.5) and gap junction...
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