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Article

The disruption of GDP-fucose de novo biosynthesis suggests the presence of a novel fucose-containing glycoconjugate in Plasmodium asexual blood stages.

Scientific reports - 16 Nov 2016

Sanz Sílvia, López-Gutiérrez Borja, Bandini Giulia, Damerow Sebastian, Absalon Sabrina, Dinglasan Rhoel R, Samuelson John, Izquierdo Luis

Abstract excerpt

Glycosylation is an important posttranslational protein modification in all eukaryotes. Besides glycosylphosphatidylinositol (GPI) anchors and N-glycosylation, O-fucosylation has been recently reported in key sporozoite proteins of the malaria parasite. Previous analyses showed the presence of GDP-fucose (GDP-Fuc), the precursor for all fucosylation reactions, in the blood stages of Plasmodium falciparum. The...

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PMID: 27849032
DOI: 10.1038/srep37230
PMCID: PMC5110956

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GPI

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

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