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Article

The nucleocytosolic O-fucosyltransferase SPINDLY affects protein expression and virulence in Toxoplasma gondii.

The Journal of biological chemistry - 1 Jan 2000

Bandini Giulia, Agop-Nersesian Carolina, van der Wel Hanke, Mandalasi Msano, Kim Hyun W, West Christopher M, Samuelson John

Abstract excerpt

Once considered unusual, nucleocytoplasmic glycosylation is now recognized as a conserved feature of eukaryotes. While in animals, O-GlcNAc transferase (OGT) modifies thousands of intracellular proteins, the human pathogen Toxoplasma gondii transfers a different sugar, fucose, to proteins involved in transcription, mRNA processing, and signaling. Knockout experiments showed that TgSPY, an ortholog of plant...

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Identifiers

PMID: 33158988
DOI: 10.1074/jbc.RA120.015883
PMCID: PMC7949088

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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