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Article

Interaction Between Rare Variants in NOTCH1 and Betel Quid Chewing in Oral Squamous Cell Carcinoma.

Genetic testing and molecular biomarkers - 1 Oct 2017

Chung Chia-Min, Lee Chien-Hung, Chen Mu-Kuan, Tsai Ming-Hsui, Ko Ying-Chin

Abstract excerpt

BACKGROUND: In this study, we investigated rare variants of the NOTCH1 gene located near somatic mutations as surrogate markers, as well as the relationship of these rare variants with betel quid (BQ) chewing and the occurrence of oral squamous cell carcinoma (OSCC). MATERIALS AND METHODS: A total of 410 patients diagnosed with OSCC and 282 unrelated, healthy subjects without cancer were recruited from two...

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Identifiers

PMID: 28910158
DOI: 10.1089/gtmb.2017.0013

Genes

NOTCH1

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