Article
Multimodal profiling of oral squamous cell carcinoma identifies genomic alterations and expression programs associated with betel quid chewing.
Neoplasia (New York, N.Y.) - 1 Oct 2025
Su Shih-Chi, Lin Chiao-Wen, Chen Mu-Kuan, Lee Yi-Chan, Su Chun-Wen, Bai Shi, Jangir Hansraj, Chuang Chun-Yi, Chung Wen-Hung, Chang Lun-Ching, Yang Shun-Fa
Abstract excerpt
Betel quid (BQ) chewing is a profound risk for oral squamous cell carcinoma (OSCC) in Southeast Asia. Yet, the detailed mechanisms by which BQ chewing damages the genome and creates a unique tumor niche that ultimately cause OSCC are still not fully understood. To address this, we conducted a multi-omics survey, including exome sequencing of tumor-normal pairs from 261 male patients with OSCC (129 habitual BQ...
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