Article
A genome-wide association study of buccal mucosa cancer in India and multi-ancestry meta-analysis discovers risk loci and gene-environment interactions.
EBioMedicine - 1 Dec 2025
Mhatre Sharayu, Dutta Diptavo, Iyer Anand, Golapkar Shruti Vishwas, Mishra Aseem, Krishnatreya Manigreeva, George Grace Sarah, Doibale Pravin Narayanrao, Dun Yuzheng, Wang Ziqiao, Jahagirdar Om, Chaturvedi Pankaj, Rajaraman Preetha, Wang Cheng-Ping, Chaturvedi Anil, Kar Siddhartha, Dikshit Rajesh, Chatterjee Nilanjan
Abstract excerpt
BACKGROUND: Genome-wide association studies (GWASs) of oral cancers (OC) to date have focused predominantly on European Ancestry (EA) populations. India faces an excess burden of OC, but the most common is the buccal mucosa cancer (BMC), which is relatively rare in EA populations. METHODS: We conducted a GWAS comprising 2160 BMC cases and 2325 controls from different geographical locations in India. We...
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