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Article

Activation Mechanism of the Streptomyces Tyrosinase Assisted by the Caddie Protein.

Biochemistry - 17 Oct 2017

Matoba Yasuyuki, Kihara Shogo, Muraki Yoshimi, Bando Naohiko, Yoshitsu Hironari, Kuroda Teruo, Sakaguchi Miyuki, Kayama Kure'e, Tai Hulin, Hirota Shun, Ogura Takashi, Sugiyama Masanori

Abstract excerpt

Tyrosinase (EC 1.14.18.1), which possesses two copper ions at the active center, catalyzes a rate-limiting reaction of melanogenesis, that is, the conversion of a phenol to the corresponding ortho-quinone. The enzyme from the genus Streptomyces is generated as a complex with a "caddie" protein that assists the transport of two copper ions into the active center. In this complex, the Tyr98 residue in the caddie...

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PMID: 28902505
DOI: 10.1021/acs.biochem.7b00635

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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