Article
Secretion of the Streptomyces tyrosinase is mediated through its trans-activator protein, MelC1.
The Journal of biological chemistry - 5 Oct 1992
Leu W M, Chen L Y, Liaw L L, Lee Y H
Abstract excerpt
The tyrosinase of Streptomyces antibioticus is encoded by the second open reading frame, melC2 of the melanin operon (melC). The upstream open reading frame melC1 specifies a 146-amino acid protein with a typical NH2-terminal signal-peptide characteristic of a secretory protein. The MelC1 protein is involved in the transfer of copper ion to apotyrosinase MelC2 via binary complex formation (Lee, Y.-H. W., Chen,...
Topics
- Amino Acid Sequence
- Base Sequence
- Chromatography, Affinity
- Melanins
- Molecular Sequence Data
- Monophenol Monooxygenase
- Mutation
- Open Reading Frames
- Phenotype
- Protein Sorting Signals
- Streptomyces