Article
A molecular mechanism for copper transportation to tyrosinase that is assisted by a metallochaperone, caddie protein.
The Journal of biological chemistry - 26 Aug 2011
Matoba Yasuyuki, Bando Naohiko, Oda Kosuke, Noda Masafumi, Higashikawa Fumiko, Kumagai Takanori, Sugiyama Masanori
Abstract excerpt
The Cu(II)-soaked crystal structure of tyrosinase that is present in a complex with a protein, designated "caddie," which we previously determined, possesses two copper ions at its catalytic center. We had identified two copper-binding sites in the caddie protein and speculated that copper bound to caddie may be transported to the tyrosinase catalytic center. In our present study, at a 1.16-1.58 Å resolution, we...
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