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Article

The basicity of an active-site water molecule discriminates between tyrosinase and catechol oxidase activity.

International journal of biological macromolecules - 31 Jul 2021

Matoba Yasuyuki, Oda Kosuke, Muraki Yoshimi, Masuda Taro

Abstract excerpt

Tyrosinase (Ty) and catechol oxidase (CO) are members of type-3 copper enzymes. While Ty catalyzes both phenolase and catecholase reactions, CO catalyzes only the latter reaction. In the present study, Ty was found to catalyze the catecholase reaction, but hardly the phenolase reaction in the presence of the metallochaperon called "caddie protein (Cad)". The ability of the substrates to dissociate the motif...

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Identifiers

PMID: 34089758
DOI: 10.1016/j.ijbiomac.2021.05.206

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