Article
The DyP-type peroxidase DtpA is a Tat-substrate required for GlxA maturation and morphogenesis in Streptomyces.
Open biology - 1 Jan 2016
Petrus Marloes L C, Vijgenboom Erik, Chaplin Amanda K, Worrall Jonathan A R, van Wezel Gilles P, Claessen Dennis
Abstract excerpt
The filamentous bacterium Streptomyces lividans depends on the radical copper oxidase GlxA for the formation of reproductive aerial structures and, in liquid environments, for the formation of pellets. Incorporation of copper into the active site is essential for the formation of a cross-linked tyrosyl-cysteine cofactor, which is needed for enzymatic activity. In this study, we show a crucial link between GlxA...
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