Article
Cooperative oncogenic effect and cell signaling crosstalk of co‑occurring HER2 and mutant PIK3CA in mammary epithelial cells.
International journal of oncology - 1 Oct 2017
Dong Lun, Meng Fanyan, Wu Ling, Mitchell Allison V, Block C James, Zhang Bin, Craig Douglas B, Jang Hyejeong, Chen Wei, Yang Qifeng, Wu Guojun
Abstract excerpt
Though incidence of PI3K oncogenic mutation is prominent in breast cancer (20-30%), pharmacological targeting of this signaling pathway alone has failed to provide meaningful clinical benefit. To better understand and address this problem, we conducted genome-wide analysis to study the association of mutant PI3K with other gene amplification events. One of the most significant copy number gain events associated...
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