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Article

Erythroleukemia cells acquire an alternative mitophagy capability

19 Apr 2016

Abstract excerpt

Leukemia cells are superior to hematopoietic cells with a normal differentiation potential in buffering cellular stresses, but the underlying mechanisms for this leukemic advantage are not fully understood. Using CRISPR/Cas9 deletion of the canonical autophagy-essential gene Atg7, we found that erythroleukemia K562 cells are armed with two sets of autophagic machinery. Alternative mitophagy is functional...

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PMID: 27091640
DOI: 10.1038/srep24641

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