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Article

Mechanoregulation of SM22α/Transgelin

12 Sept 2017

Abstract excerpt

SM22α, also named transgelin, is an actin filament-associated protein in smooth muscle and fibroblasts. Three decades after its discovery, the biological function of SM22α remains under investigation. Here we report a novel finding that the expression and degradation of SM22α/transgelin are regulated by mechanical tension. Following a mass spectrometry identification of SM22α degradation in isolated and...

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PMID: 28898058
DOI: 10.1021/acs.biochem.7b00794

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