Article
Phenotypic responses to mechanical stress in fibroblasts from tendon, cornea and skin.
The Biochemical journal - 1 Jun 2006
Mackley Jennifer R, Ando Joji, Herzyk Pawel, Winder Steven J
Abstract excerpt
Primary fibroblasts isolated from foetal mouse cornea, skin and tendon were subjected to linear shear stress and analysed for morphological parameters and by microarray, as compared with unstimulated controls. Approx. 350 genes were either up- or down-regulated by a significant amount, with 51 of these being common to all three cell types. Approx. 50% of altered genes in tendon and cornea fibroblasts were changed...
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