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Article

The Candida albicans transcription factor Cas5 couples stress responses, drug resistance and cell cycle regulation.

Nature communications - 11 Sept 2017

Xie Jinglin L, Qin Longguang, Miao Zhengqiang, Grys Ben T, Diaz Jacinto De La Cruz, Ting Kenneth, Krieger Jonathan R, Tong Jiefei, Tan Kaeling, Leach Michelle D, Ketela Troy, Moran Michael F, Krysan Damian J, Boone Charles, Andrews Brenda J, Selmecki Anna, Ho Wong Koon, Robbins Nicole, Cowen Leah E

Abstract excerpt

The capacity to coordinate environmental sensing with initiation of cellular responses underpins microbial survival and is crucial for virulence and stress responses in microbial pathogens. Here we define circuitry that enables the fungal pathogen Candida albicans to couple cell cycle dynamics with responses to cell wall stress induced by echinocandins, a front-line class of antifungal drugs. We discover that the...

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Identifiers

PMID: 28894103
DOI: 10.1038/s41467-017-00547-y
PMCID: PMC5593949

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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