Article
Polymorphism in IFI16 affects CD4(+) T-cell counts in HIV-1 infection.
International journal of immunogenetics - 1 Dec 2014
Booiman T, Kootstra N A
Abstract excerpt
Interferon-γ-inducible protein 16 (IFI16) plays a pivotal role in the death of bystander CD4(+) T-cells. Here, we demonstrate that SNP rs1417806 in IFI16 is associated with CD4(+) T-cell counts at set point and HIV-1 disease progression, indicating that IFI16 affects HIV-1 pathogenesis especially during the early phase of infection.
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