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Article

Serine racemase deficiency attenuates choroidal neovascularization and reduces nitric oxide and VEGF levels by retinal pigment epithelial cells.

Journal of neurochemistry - 1 Nov 2017

Jiang Haiyan, Wu Mengjuan, Liu Yimei, Song Liping, Li Shifeng, Wang Xianwei, Zhang Yun-Feng, Fang Junxu, Wu Shengzhou

Abstract excerpt

Choroidal neovascularization (CNV) is a leading cause of blindness in age-related macular degeneration. Production of vascular endothelial growth factor (VEGF) and macrophage recruitment by retinal pigment epithelial cells (RPE) significantly contributes to the process of CNV in an experimental CNV model. Serine racemase (SR) is expressed in retinal neurons and glial cells, and its product, d-serine, is an...

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Source

Identifiers

PMID: 28892569
DOI: 10.1111/jnc.14214

Genes

RPE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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