Article
Germline and Somatic NF1 Alterations Are Linked to Increased HER2 Expression in Breast Cancer.
Cancer prevention research (Philadelphia, Pa.) - 1 Oct 2018
Wang Xia, Kallionpää Roope A, Gonzales Patrick R, Chitale Dhananjay A, Tousignant Renee N, Crowley Jacob P, Chen Zhihua, Yoder Sean J, Blakeley Jaishri O, Acosta Maria T, Korf Bruce R, Messiaen Ludwine M, Tainsky Michael A
Abstract excerpt
NF1 germline mutation predisposes to breast cancer. NF1 mutations have also been proposed as oncogenic drivers in sporadic breast cancers. To understand the genomic and histologic characteristics of these breast cancers, we analyzed the tumors with NF1 germline mutations and also examined the genomic and proteomic profiles of unselected tumors. Among 14 breast cancer specimens from 13 women affected with...
Topics
Join the communities discussing this publication.