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Synthetic Modular Antibody Construction by Using the SpyTag/SpyCatcher Protein‐Ligase System

10 Sept 2017

Abstract excerpt

Efforts to engineer recombinant antibodies for specific diagnostic and therapy applications are time consuming and expensive, as each new recombinant antibody needs to be optimized for expression, stability, bio-distribution, and pharmacokinetics. We have developed a new way to construct recombinant antibody-like "devices" by using a bottom-up approach to build them from well-behaved discrete recombinant antibody...

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PMID: 28891272
DOI: 10.1002/cbic.201700411

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