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Article

Mechanistic and Fc requirements for inhibition of Sudan virus entry and in vivo protection by a synthetic antibody.

Immunology letters - 1 Oct 2017

Hofmann Daniel, Zak Samantha E, Nyakatura Elisabeth K, Mittler Eva, Bakken Russell R, Chandran Kartik, Dye John M, Lai Jonathan R

Abstract excerpt

The Sudan virus (SUDV), an ebolavirus, causes severe hemorrhagic fever with human case fatality rates of ∼50%. Previous work from our lab demonstrated the synthetic antibody F4 potently inhibits viral entry and protects against lethal virus challenge in mice [Chen et al., ACS Chem. Biol., 2014, 9, 2263-2273]. Here, we explore mechanistic requirements as well as contribution of the Fc region and function on...

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Share to Antibodies, Neutralizing
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Hemorrhagic Fever, Ebola

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Source

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Identifiers

PMID: 28890093
DOI: 10.1016/j.imlet.2017.09.002
PMCID: PMC6719535

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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