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Molecular Mechanism for Antibody-Dependent Enhancement of Coronavirus Entry

9 Dec 2019

Abstract excerpt

Antibody-dependent enhancement (ADE) of viral entry has been observed for many viruses. It was shown that antibodies target one serotype of viruses but only subneutralize another, leading to ADE of the latter viruses. Here we identify a novel mechanism for ADE: a neutralizing antibody binds to the surface spike protein of coronaviruses like a viral receptor, triggers a conformational change of the spike, and...

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PMID: 31826992
DOI: 10.1128/jvi.02015-19

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