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Article

Quantification of volume and lipid filling of intracellular vesicles carrying the ABCA3 transporter.

Biochimica et biophysica acta. Molecular cell research - 1 Dec 2017

Höppner Stefanie, Kinting Susanna, Torrano Adriano A, Schindlbeck Ulrike, Bräuchle Christoph, Zarbock Ralf, Wittmann Thomas, Griese Matthias

Abstract excerpt

The ABCA3 lipid transporter is located in the limiting membrane of lamellar bodies (LBs) in type-II-pneumocytes. Mutations within the ABCA3 gene may functionally impair the transporter, causing lung diseases in newborns, children and adults. Assays to quantify volume and lipid filling of the LBs on the level of the vesicular structures and thereby assess the function of ABCA3 are still lacking. In the present...

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Identifiers

PMID: 28887056
DOI: 10.1016/j.bbamcr.2017.08.013

Genes

ABCA3

Variants

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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