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Article

Ancient Evolution and Dispersion of Human Papillomavirus 58 Variants.

Journal of virology - 1 Nov 2017

Chen Zigui, Ho Wendy C S, Boon Siaw Shi, Law Priscilla T Y, Chan Martin C W, DeSalle Rob, Burk Robert D, Chan Paul K S

Abstract excerpt

Human papillomavirus 58 (HPV58) is found in 10 to 18% of cervical cancers in East Asia but is rather uncommon elsewhere. The distribution and oncogenic potential of HPV58 variants appear to be heterogeneous, since the E7 T20I/G63S variant is more prevalent in East Asia and confers a 7- to 9-fold-higher risk of cervical precancer and cancer. However, the underlying genomic mechanisms that explain the geographic...

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Identifiers

PMID: 28794033
DOI: 10.1128/JVI.01285-17
PMCID: PMC5640864

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