Article
Long-term effects of rituximab in rheumatoid arthritis: clinical, biologic, and pharmacogenetic aspects.
Annals of the New York Academy of Sciences - 1 Sept 2009
Quartuccio Luca, Lombardi Sandra, Fabris Martina, Masolini Paola, Saracco Marta, Pellerito Raffaele, De Vita Salvatore
Abstract excerpt
Rituximab selectively targets the B-cell compartment, including rheumatoid factor-positive B cells. Short-term efficacy and safety of rituximab in rheumatoid arthritis (RA) has been established by multicenter randomized placebo-controlled studies. Results of long-term follow-up of the phase II/III clinical trials have confirmed the efficacy and safety of repeated courses of rituximab in the responders. However,...
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