Article
Differential Antigen-presenting B Cell Phenotypes from Synovial Microenvironment of Patients with Rheumatoid and Psoriatic Arthritis.
The Journal of rheumatology - 1 Oct 2015
Armas-González Estefanía, Díaz-Martín Ana, Domínguez-Luis María Jesús, Arce-Franco María Teresa, Herrera-García Ada, Hernández-Hernández María Vanesa, Bustabad Sagrario, Usategui Alicia, Pablos José L, Cañete Juan D, Díaz-González Federico
Abstract excerpt
OBJECTIVE: To study the qualitative and quantitative phenotypic changes that occur in molecules involved in antigen presentation and costimulation in synovial B cells from rheumatoid arthritis (RA) and psoriatic arthritis (PsA). METHODS: The presence of HLA-DR, CD86, and CD40 in CD20+ cells was studied in RA synovium biopsies using immunohistochemistry and immunofluorescence. Expression was assessed by flow...
Topics
- Adult
- Aged
- Arthritis, Psoriatic
- Arthritis, Rheumatoid
- B-Lymphocytes
- Biomarkers
- Cells, Cultured
- Cohort Studies
- Female
- Flow Cytometry
- Humans
- Immunophenotyping
- Male