Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

A Genetic Variant of ASCT2 Hampers In Vitro RNA Splicing and Correlates with Human Longevity.

Rejuvenation research - 1 Jun 2018

D'Aquila Patrizia, Crocco Paolina, De Rango Francesco, Indiveri Cesare, Bellizzi Dina, Rose Giuseppina, Passarino Giuseppe

Abstract excerpt

Given the role of amino acid regulation for physiological and pathological cell proliferation, we investigated whether the variability of solute carrier family 1, member 5 (SLC1A5, namely ASCT2), encoding for ASCT2 protein, a major glutamine transporter, is related to longevity. A total of 607 differently aged unrelated individuals, 351 very old subjects (≥85 years, range 85-106 years, mean age 93.82 ± 4.44...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alternative Splicing
Share to Exons

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to HeLa Cells

Share to Longevity

Share to Minor Histocompatibility Antigens

Share to Reverse Transcriptase Polymerase Chain Reaction

Share to RNA Splicing

Share to Transfection

Source

Identifiers

PMID: 28885889
DOI: 10.1089/rej.2017.1948

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A Genetic Variant of ASCT2 Hampers In Vitro RNA Splicing and Correlates with Human Longevity.PMID 28885889Read ↗

SNP rs6543176 is associated with extreme human longevity but increased risk for cancer.Semantic proximity Read ↗

Physical decline and survival in the elderly are affected by the genetic variability of amino acid transporter genes.Semantic proximity Read ↗

Alternative splicing in aging and longevity.Semantic proximity Read ↗

Allele-Specific Reprogramming of Cancer Metabolism by the Long Non-coding RNA CCAT2.Semantic proximity Read ↗

Organization and expression of the SLC36 cluster of amino acid transporter genes.Semantic proximity Read ↗

Ataxia-telangiectasia mutated (ATM) genetic variant in Italian centenarians.Semantic proximity Read ↗

Association of SLC34A2 variation and sodium-lithium countertransport activity in humans and baboons.Semantic proximity Read ↗

Search for a Functional Genetic Variant Mimicking the Effect of SGLT2 Inhibitor Treatment.Semantic proximity Read ↗

Novel human ABCC9/SUR2 brain-expressed transcripts and an eQTL relevant to hippocampal sclerosis of aging.Semantic proximity Read ↗

The IRS2 Gly1057Asp variant is associated with human longevity.Semantic proximity Read ↗

Common variants in glutamine:fructose-6-phosphate amidotransferase 2 (GFPT2) gene are associated with type 2 diabetes, diabetic nephropathy, and increased GFPT2 mRNA levels.Semantic proximity Read ↗

Functional genetic diversity in the high-affinity carnitine transporter OCTN2 (SLC22A5).Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.