SNP rs6543176 is associated with extreme human longevity but increased risk for cancer.

doi:10.1007/s11357-024-01478-5

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Community

Back to search

Article

SNP rs6543176 is associated with extreme human longevity but increased risk for cancer.

GeroScience - 1 Jun 2025

Gurinovich Anastasia, Song Zeyuan, Bae Harold, Leshchyk Anastasia, Li Mengze, Lords Hannah, Andersen Stacy L, Nygaard Marianne, Christensen Kaare, Daw E Warwick, Arbeev Konstantin G, Brent Michael R, Perls Thomas T, Sebastiani Paola

Abstract excerpt

Using whole-genome sequencing (WGS) might offer insights into rare genetic variants associated with healthy aging and extreme longevity (EL), potentially pointing to useful therapeutic targets. In this study, we conducted a genome-wide association study using WGS data from the Long Life Family Study and identified a novel longevity-associated variant rs6543176 in the SLC9A2 gene. This SNP also showed a...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Aged

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Aged, 80 and over

Share to Alleles

Share to Genome-Wide Association Study

Share to Longevity

Share to Neoplasms

Share to Polymorphism, Single Nucleotide

Share to Whole Genome Sequencing

Source

Open in PubMed Open full text

Identifiers

PMID: 39751714
DOI: 10.1007/s11357-024-01478-5
PMCID: PMC12181136

Genes

SLC9A2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.