Article

Computational analysis and visualization of MYO5B mutations provide novel insights into the pathogenic mechanisms of MVID

2026-04-15

Abstract excerpt

<title>Abstract</title> Background Mutations in the MYO5B gene result in functional deficiency of myosin Vb, ultimately leading to microvillus inclusion disease (MVID). This study aimed to capture subtle conformational and dynamic changes in myosin Vb protein caused by specific MYO5B mutations through computational analysis, thereby elucidating the pathogenic mechanism of compound heterozygous variants and em...

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Literature Corpus work: 5b3e84b5-a0e7-598f-b38e-b2e30d1a29b4
DOI: 10.21203/rs.3.rs-7073476/v1

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