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Article

Runx1 mediates the development of the granular convoluted tubules in the submandibular glands.

PloS one - 1 Jan 2017

Ono Minagi Hitomi, Sarper Safiye Esra, Kurosaka Hiroshi, Kuremoto Koh-Ichi, Taniuchi Ichiro, Sakai Takayoshi, Yamashiro Takashi

Abstract excerpt

The mouse granular convoluted tubules (GCTs), which are only located in the submandibular gland (SMG) are known to develop and maintain their structure in an androgen-dependent manner. We previously demonstrated that the GCTs are involuted by the epithelial deletion of core binding factor β (CBFβ), a transcription factor that physically interacts with any of the Runt-related transcription factor (RUNX) proteins...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Core Binding Factor Alpha 2 Subunit

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Share to Gene Expression Regulation, Developmental

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Share to Microscopy, Fluorescence

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Source

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Identifiers

PMID: 28877240
DOI: 10.1371/journal.pone.0184395
PMCID: PMC5587342

Genes

AQP5
RUNX1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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