Article
Runx/Cbfb signaling regulates postnatal development of granular convoluted tubule in the mouse submandibular gland.
Developmental dynamics : an official publication of the American Association of Anatomists - 1 Mar 2015
Islam Md Nurul, Itoh Shinsuke, Yanagita Takeshi, Sumiyoshi Kumi, Hayano Satoru, Kuremoto Koh-Ichi, Kurosaka Hiroshi, Honjo Tadashi, Kawanabe Noriaki, Kamioka Hiroshi, Sakai Takayoshi, Ishimaru Naozumi, Taniuchi Ichiro, Yamashiro Takashi
Abstract excerpt
BACKGROUND: The rodent salivary gland is not fully developed at birth and the cellular definitive differentiation takes place postnatally. However, little is known about its molecular mechanism. RESULTS: Here we provide the loss-of-function genetic evidence that Runx signaling affects postnatal development of the submandibular gland (SMG). Core binding factor β (Cbfb) is a cotranscription factor which forms a...
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