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DNA methylation of the allergy regulatory gene interferon gamma varies by age, sex, and tissue type in asthmatics

22 May 2014

Abstract excerpt

BACKGROUND: Asthma is associated with allergic sensitization in about half of all cases, and asthma phenotypes can vary by age and sex. DNA methylation in the promoter of the allergy regulatory gene interferon gamma (IFNγ) has been linked to the maintenance of allergic immune function in human cell and mouse models. We hypothesized that IFNγ promoter methylation at two well-studied, key cytosine phosphate guanine...

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PMID: 24891923
DOI: 10.1186/1868-7083-6-9

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