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Article

Interaction of HIV-1 Nef with the cellular dileucine-based sorting pathway is required for CD4 down-regulation and optimal viral infectivity.

Proceedings of the National Academy of Sciences of the United States of America - 15 Sept 1998

Craig H M, Pandori M W, Guatelli J C

Abstract excerpt

The HIV-1 Nef protein is important for pathogenesis, enhances viral infectivity, and regulates the sorting of at least two cellular transmembrane proteins, CD4 and major histocompatibility complex (MHC) class I. Although several lines of evidence support the hypothesis that the Nef protein intera...

Topics

CD4 Antigens
Cell Line
Down-Regulation
Endocytosis
Flow Cytometry
Gene Products, nef
HIV-1
Membrane Proteins
Mutation
Signal Transduction
Transfection
Viral Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

nef Gene Products, Human Immunodeficiency Virus

Source

Open in PubMed Open full text

Identifiers

PMID: 9736718
DOI: 10.1073/pnas.95.19.11229
PMCID: PMC21624

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9736718-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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Interaction of HIV-1 Nef with the cellular dileucine-based sorting pathway is required for CD4 down-regulation and optimal viral infectivity.PMID 9736718Read ↗

A dileucine motif in HIV-1 Nef is essential for sorting into clathrin-coated pits and for downregulation of CD4Semantic proximity Read ↗

Endocytic sorting motif interactions involved in Nef-mediated downmodulation of CD4 and CD3.Semantic proximity Read ↗

Dissociation of the CD4 downregulation and viral infectivity enhancement functions of human immunodeficiency virus type 1 NefSemantic proximity Read ↗

A dileucine motif in HIV-1 Nef acts as an internalization signal for CD4 downregulation and binds the AP-1 clathrin adaptorSemantic proximity Read ↗

Conformation of the Dileucine‐Based Sorting Motif in HIV‐1 Nef Revealed by Intermolecular Domain AssemblySemantic proximity Read ↗

HIV ‐1 Nef: Taking Control of Protein TraffickingSemantic proximity Read ↗

Identification of a novel binding site between HIV type 1 Nef C-terminal flexible loop and AP2 required for Nef-mediated CD4 downregulation.Semantic proximity Read ↗

HIV-1 Nef disrupts intracellular trafficking of major histocompatibility complex class I, CD4, CD8, and CD28 by distinct pathways that share common elements.Semantic proximity Read ↗

Nef-induced CD4 downregulation: a diacidic sequence in human immunodeficiency virus type 1 Nef does not function as a protein sorting motif through direct binding to beta-COP.Semantic proximity Read ↗

Human Immunodeficiency Virus Type 1 Nef: Adapting to Intracellular Trafficking PathwaysSemantic proximity Read ↗

An interdomain binding site on HIV-1 Nef interacts with PACS-1 and PACS-2 on endosomes to down-regulate MHC-I.Semantic proximity Read ↗

The di-leucine motif in the cytoplasmic tail of CD4 is not required for binding to human immunodeficiency virus type 1 Nef, but is critical for CD4 down-modulation.Semantic proximity Read ↗

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