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Article

Immunodeficiency and Intermittent Dosing Promote Acquired Rifamycin Monoresistance in Murine Tuberculosis.

Antimicrobial agents and chemotherapy - 1 Nov 2017

Park Sang-Won, Tasneen Rokeya, Converse Paul J, Nuermberger Eric L

Abstract excerpt

More-permissive preclinical models may be useful in evaluating antituberculosis regimens for their propensity to select drug-resistant mutants. To evaluate whether acquired rifamycin monoresistance could be recapitulated in mice and, if so, to evaluate the effects of immunodeficiency, intermittent dosing, and drug exposures, athymic nude and BALB/c mice were infected. Controls received daily rifapentine alone or...

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Identifiers

PMID: 28874368
DOI: 10.1128/AAC.01502-17
PMCID: PMC5655103

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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