Article
Consequences of noncompliance for therapy efficacy and emergence of resistance in murine tuberculosis caused by the Beijing genotype of Mycobacterium tuberculosis.
Antimicrobial agents and chemotherapy - 1 Sept 2012
de Steenwinkel Jurriaan E M, ten Kate Marian T, de Knegt Gerjo J, Verbrugh Henri A, Aarnoutse Rob E, Boeree Martin J, den Bakker Michael A, van Soolingen Dick, Bakker-Woudenberg Irma A J M
Abstract excerpt
Despite great effort by health organizations worldwide in fighting tuberculosis (TB), morbidity and mortality are not declining as expected. One of the reasons is related to the evolutionary development of Mycobacterium tuberculosis, in particular the Beijing genotype strains. In a previous study, we showed the association between the Beijing genotype and an increased mutation frequency for rifampin resistance....
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