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Article

Japanese genome-wide association study identifies a significant colorectal cancer susceptibility locus at chromosome 10p14.

Cancer science - 1 Nov 2017

Takahashi Yusuke, Sugimachi Keishi, Yamamoto Ken, Niida Atsushi, Shimamura Teppei, Sato Tetsuya, Watanabe Masahiko, Tanaka Junichi, Kudo Shinei, Sugihara Kenichi, Hase Kazuo, Kusunoki Masato, Yamada Kazutaka, Shimada Yasuhiro, Moriya Yoshihiro, Suzuki Yutaka, Miyano Satoru, Mori Masaki, Mimori Koshi

Abstract excerpt

Genome-wide association studies are a powerful tool for searching for disease susceptibility loci. Several studies identifying single nucleotide polymorphisms (SNP) connected intimately to the onset of colorectal cancer (CRC) have been published, but there are few reports of genome-wide association studies in Japan. To identify genetic variants that modify the risk of CRC oncogenesis, especially in the Japanese...

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PMID: 28869801
DOI: 10.1111/cas.13391
PMCID: PMC5665761

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