Article
SULT1A1 gene deletion in BRCA2-associated male breast cancer: a link between genes and environmental exposures?
Journal of cellular and molecular medicine - 1 May 2013
Palli Domenico, Rizzolo Piera, Zanna Ines, Silvestri Valentina, Saieva Calogero, Falchetti Mario, Navazio Anna Sara, Graziano Veronica, Masala Giovanna, Bianchi Simonetta, Russo Antonio, Tommasi Stefania, Ottini Laura
Abstract excerpt
SULT1A1, a member of sulfotransferase superfamily, is a drug and hormone metabolizing enzyme involved in the metabolism of a variety of potential mammary carcinogens of endogenous and exogenous origin. Interestingly, the metabolic activity of SULT1A1 can be affected by variations in gene copy number. Male Breast Cancer (MBC) is a rare disease and less investigated disease compared to female BC (FBC). As in FBC,...
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