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Methyleugenol DNA adducts in human liver are associated with SULT1A1 copy number variations and expression levels.

Archives of toxicology - 1 Oct 2017

Tremmel Roman, Herrmann Kristin, Engst Wolfram, Meinl Walter, Klein Kathrin, Glatt Hansruedi, Zanger Ulrich M

Abstract excerpt

Methyleugenol is a rodent hepatocarcinogen occurring in many herbs and spices as well as essential oils used for flavoring. Following metabolic activation by cytochromes P450 (CYPs) and sulfotransferases (SULTs), methyleugenol can form DNA adducts. Previously, we showed that DNA adduct formation by methyleugenol in mouse liver is dependent on SULT1A1 expression and that methyleugenol DNA adducts are abundant in...

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PMID: 28326452
DOI: 10.1007/s00204-017-1955-4

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