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Functionally redundant roles of ID family proteins in spermatogonial stem cells

26 Sept 2024

Abstract excerpt

Spermatogonial stem cells (SSCs) are essential for sustained sperm production, but SSC regulatory mechanisms and markers remain poorly defined. Studies have suggested that the Id family transcriptional regulator Id4 is expressed in SSCs and involved in SSC maintenance. Here, we used reporter and knockout models to define the expression and function of Id4 in the adult male germline. Within the spermatogonial...

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PMID: 39332405
DOI: 10.1016/j.stemcr.2024.08.011

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