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Article

Overlapping functions of bone sialoprotein and pyrophosphate regulators in directing cementogenesis.

Bone - 1 Dec 2017

Ao M, Chavez M B, Chu E Y, Hemstreet K C, Yin Y, Yadav M C, Millán J L, Fisher L W, Goldberg H A, Somerman M J, Foster B L

Abstract excerpt

Although acellular cementum is essential for tooth attachment, factors directing its development and regeneration remain poorly understood. Inorganic pyrophosphate (PPi), a mineralization inhibitor, is a key regulator of cementum formation: tissue-nonspecific alkaline phosphatase (Alpl/TNAP) null mice (increased PPi) feature deficient cementum, while progressive ankylosis protein (Ank/ANK) null mice (decreased...

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Share to Diphosphates
Share to Calcification, Physiologic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Gene Expression Regulation

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Share to Phosphate Transport Proteins

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Source

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Identifiers

PMID: 28866368
DOI: 10.1016/j.bone.2017.08.027
PMCID: PMC5730356

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