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Article

Hypercementosis Associated with ENPP1 Mutations and GACI.

Journal of dental research - 1 Apr 2018

Thumbigere-Math V, Alqadi A, Chalmers N I, Chavez M B, Chu E Y, Collins M T, Ferreira C R, FitzGerald K, Gafni R I, Gahl W A, Hsu K S, Ramnitz M S, Somerman M J, Ziegler S G, Foster B L

Abstract excerpt

Mineralization of bones and teeth is tightly regulated by levels of extracellular inorganic phosphate (Pi) and pyrophosphate (PPi). Three regulators that control pericellular concentrations of Pi and PPi include tissue-nonspecific alkaline phosphatase (TNAP), progressive ankylosis protein (ANK), and ectonucleotide pyrophosphatase/phosphodiesterase 1 (ENPP1). Inactivation of these factors results in mineralization...

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Source

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Identifiers

PMID: 29244957
DOI: 10.1177/0022034517744773
PMCID: PMC5863873

Genes

ENPP1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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