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Article

Absence of bone sialoprotein (BSP) impairs primary bone formation and resorption: the marrow ablation model under PTH challenge.

Bone - 1 May 2012

Wade-Gueye Ndéye Marième, Boudiffa Maya, Vanden-Bossche Arnaud, Laroche Norbert, Aubin Jane E, Vico Laurence, Lafage-Proust Marie-Hélène, Malaval Luc

Abstract excerpt

Bone sialoprotein (BSP) is highly expressed in early bone deposition and may play a part in primary bone mineralization. We previously showed that while BSP−/− mice have a mild secondary bone phenotype and are responsive to mechanical (unloading) and hormonal (ovariectomy, parathyroid hormone (PTH)) challenges, repair of a cortical bone defect, which involves primary bone deposition is significantly delayed in...

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Source

Identifiers

PMID: 22586700
DOI: 10.1016/j.bone.2012.02.014

Genes

PTH
DMP1
MEPE
RUNX2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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