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Article

Aberrant cementum phenotype associated with the hypophosphatemic hyp mouse.

Journal of periodontology - 1 Aug 2009

Fong H, Chu E Y, Tompkins K A, Foster B L, Sitara D, Lanske B, Somerman M J

Abstract excerpt

BACKGROUND: Cementogenesis is sensitive to altered local phosphate levels; thus, we hypothesized a cementum phenotype, likely of decreased formation, would be present in the teeth of X-linked hypophosphatemic (Hyp) mice. Mutations in the phosphate-regulating gene with homologies to endopeptidases on the X chromosome (Phex) cause X-linked hypophosphatemia, characterized by rickets, osteomalacia, and...

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Identifiers

PMID: 19656036
DOI: 10.1902/jop.2009.090129
PMCID: PMC2776621

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Aberrant cementum phenotype associated with the hypophosphatemic hyp mouse.PMID 19656036Read ↗

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Phex mutation causes overexpression of FGF23 in teeth.Semantic proximity Read ↗

Tooth root dentin mineralization defects in a mouse model of hypophosphatasia.Semantic proximity Read ↗

Defective Mineralization in X-Linked Hypophosphatemia Dental Pulp Cell Cultures.Semantic proximity Read ↗

Dental defects in the primary dentition associated with hypophosphatasia from biallelic ALPL mutations.Semantic proximity Read ↗

Partial rescue of the Hyp phenotype by osteoblast-targeted PHEX (phosphate-regulating gene with homologies to endopeptidases on the X chromosome) expression.Semantic proximity Read ↗

Dentin sialoprotein and dentin phosphoprotein have distinct roles in dentin mineralization.Semantic proximity Read ↗

Hypercementosis Associated with ENPP1 Mutations and GACI.Semantic proximity Read ↗

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