Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Topics Community

Article

The evolutionary epidemiology of multilocus drug resistance.

Evolution; international journal of organic evolution - 1 May 2012

Day Troy, Gandon Sylvain

Abstract excerpt

The evolution of resistance to drugs is a major public health concern as it erodes the efficacy of our therapeutic arsenal against bacterial, viral, and fungal pathogens. Increasingly, it is recognized that the evolution of resistance involves genetic changes at more than one locus, both in cases where multiple changes are required to obtain high-level resistance, and where compensatory changes at secondary loci...

Topics

Drug Resistance
Epidemiologic Methods
Epistasis, Genetic
Evolution, Molecular
Genetic Variation
Models, Genetic
Multifactorial Inheritance
Recombination, Genetic
Selection, Genetic

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 22519792
DOI: 10.1111/j.1558-5646.2011.01533.x

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

0

discussions

0

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The evolutionary epidemiology of multilocus drug resistance.PMID 22519792Read ↗

The population genetics of drug resistance evolution in natural populations of viral, bacterial and eukaryotic pathogens.Semantic proximity Read ↗

Phenotypic Heterogeneity Facilitates Survival While Hindering the Evolution of Drug Resistance Due to Intraspecific CompetitionSemantic proximity Read ↗

Does High-Dose Antimicrobial Chemotherapy Prevent the Evolution of Resistance?Semantic proximity Read ↗

The origins and spread of antimalarial drug resistance: lessons for policy makers.Semantic proximity Read ↗

Genome Dynamics and Evolution of Multiple-Drug-Resistant Bacteria: Implications for Global Infection Control Priorities.Semantic proximity Read ↗

Mutation and recombination in pathogen evolution: Relevance, methods and controversies.Semantic proximity Read ↗

Evolutionary rescue of a parasite population by mutation rate evolution.Semantic proximity Read ↗

Non-genetic resistance facilitates survival while hindering the evolution of drug resistance due to intraspecific competition.Semantic proximity Read ↗

The evolution of drug resistance and the curious orthodoxy of aggressive chemotherapySemantic proximity Read ↗

Evolution of Drug Resistance in Tuberculosis: Recent Progress and Implications for Diagnosis and TherapySemantic proximity Read ↗

Imperfect drug penetration leads to spatial monotherapy and rapid evolution of multi-drug resistanceSemantic proximity Read ↗

Understanding the evolution of multiple drug resistance in structured populations.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.