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Article

Long-term expansion, enhanced chondrogenic potential, and suppression of endochondral ossification of adult human MSCs via WNT signaling modulation.

Stem cell reports - 10 Mar 2015

Narcisi Roberto, Cleary Mairéad A, Brama Pieter A J, Hoogduijn Martin J, Tüysüz Nesrin, ten Berge Derk, van Osch Gerjo J V M

Abstract excerpt

Mesenchymal stem cells (MSCs) are a potential source of chondrogenic cells for the treatment of cartilage disorders, but loss of chondrogenic potential during in vitro expansion and the propensity of cartilage to undergo hypertrophic maturation impede their therapeutic application. Here we report that the signaling protein WNT3A, in combination with FGF2, supports long-term expansion of human bone marrow-derived...

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Source

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Identifiers

PMID: 25733021
DOI: 10.1016/j.stemcr.2015.01.017
PMCID: PMC4375944

Genes

FGF2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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