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Article

Drug sensitivity in cancer cell lines is not tissue-specific

15 Feb 2015

Abstract excerpt

BACKGROUND: Cancer cell lines have a prominent role in the initial stages of drug discovery, facilitating high-throughput screening of potential drugs. However, their clinical relevance remains controversial. FINDINGS: We assess whether drug sensitivity in cancer cell lines is able to discriminate tissue specificity. We find that cancer-specific drugs do not show higher efficacies in cell lines representing the...

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PMID: 25881072
DOI: 10.1186/s12943-015-0312-6

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