Prevalent somatic BRCA1 mutations shape clinically relevant genomic patterns of nasopharyngeal carcinoma in Southeast Europe.

doi:10.1002/ijc.31023

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Article

Prevalent somatic BRCA1 mutations shape clinically relevant genomic patterns of nasopharyngeal carcinoma in Southeast Europe.

International journal of cancer - 1 Jan 2018

Fountzilas George, Psyrri Amanda, Giannoulatou Eleni, Tikas Ioannis, Manousou Kyriaki, Rontogianni Dimitra, Ciuleanu Elisabeta, Ciuleanu Tudor, Resiga Liliana, Zaramboukas Thomas, Papadopoulou Kyriaki, Bobos Mattheos, Chrisafi Sofia, Tsolaki Eleftheria, Markou Konstantinos, Giotakis Evangelos, Koutras Angelos, Psoma Elsa, Kalogera-Fountzila Anna, Skondra Maria, Bamia Christina, Pectasides Dimitrios, Kotoula Vassiliki

Abstract excerpt

Genomic patterns of nasopharyngeal carcinomas (NPCs) have as yet been studied in Southeast Asian (SEA) patients. Here, we investigated genomic patterns of locally advanced NPC Southeast European (SEE) patients treated with chemoradiotherapy. We examined 126 tumors (89% EBV positive) from Greek and Romanian NPC patients with massively parallel sequencing. Paired tumor-cell-rich (TC) and...

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Identifiers

PMID: 28857155
DOI: 10.1002/ijc.31023

Genes

BRCA1
SEA
BRCA2
KRAS

Provenance

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