Article
MET-GRB2 Signaling-Associated Complexes Correlate with Oncogenic MET Signaling and Sensitivity to MET Kinase Inhibitors.
Clinical cancer research : an official journal of the American Association for Cancer Research - 15 Nov 2017
Smith Matthew A, Licata Thomas, Lakhani Aliya, Garcia Marileila Varella, Schildhaus Hans-Ulrich, Vuaroqueaux Vincent, Halmos Balazs, Borczuk Alain C, Chen Y Ann, Creelan Benjamin C, Boyle Theresa A, Haura Eric B
Abstract excerpt
Purpose: Targeting MET in cancer is hampered by lack of diagnostics that accurately reflect high MET signaling and dependence. We hypothesized that assays reflecting MET signaling associated protein complexes could redefine tumors dependent on MET and could add additional precision beyond genomic assessments.Experimental Design: We used biochemical approaches, cellular viability studies, and proximity ligation...
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