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Article

Loss of Motor Protein MYO1C Causes Rhodopsin Mislocalization and Results in Impaired Visual Function.

Cells - 26 May 2021

Solanki Ashish K, Biswal Manas R, Walterhouse Stephen, Martin René, Kondkar Altaf A, Knölker Hans-Joachim, Rahman Bushra, Arif Ehtesham, Husain Shahid, Montezuma Sandra R, Nihalani Deepak, Lobo Glenn Prazere

Abstract excerpt

Unconventional myosins, linked to deafness, are also proposed to play a role in retinal cell physiology. However, their direct role in photoreceptor function remains unclear. We demonstrate that systemic loss of the unconventional myosin MYO1C in mice, specifically causes rhodopsin mislocalization, leading to impaired visual function. Electroretinogram analysis of Myo1c knockout (Myo1c-KO) mice showed a...

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Identifiers

PMID: 34073294
DOI: 10.3390/cells10061322
PMCID: PMC8229726

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